Phase I Metabolic Reactions
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Pharmacology
Phase I Metabolic Reactions
Ancient enzymes transform modern drugs, sometimes creating unexpected toxic byproducts
5 days ago
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Why are Phase I metabolic reactions essential before Phase II conjugation in drug metabolism?
Because Phase I reactions directly excrete drugs without further modification.
Because Phase I reactions introduce or expose functional groups that increase drug polarity, enabling effective conjugation in Phase II.
Because Phase I reactions always detoxify drugs without producing any reactive intermediates.
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